教員紹介

氏名
  高橋 吉孝 TAKAHASHI, Yoshitaka
職位
  教授
E-Mail
  ytaka●fhw.oka-pu.ac.jp(●を@に変更)
研究室番号
  6208







担当科目
  【学部】病態栄養学、応用栄養生理学、代謝生化学、薬理学、解剖生理学実験I、臨床栄養学実験
【博士前期課程】病態栄養学特論、保健栄養学特別研究
【博士後期課程】脂質分子病態科学特別講義、応用栄養学特別研究
業績
 
  1. Yoshimura Y, Araki A, Maruta H, Takahashi Y, Yamashita H. 2017 Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix. J Biochem. (Tokyo) 161(3): 279-289.
  2. Kawakami Y, Kinoshita M, Mori Y, Okochi S, Hirano S, Shimoda I, Kanzaki K, Suzuki-Yamamoto T, Kimoto M, Sugahara M, Hori T, Saino H, Miyano Masashi, Yamamoto S, Takahashi Y. 2017 The Y54(L)W mutation of anti-leukotriene C4 single-chain antibody increases affinity to leukotriene E4. J Biochem. (Tokyo) 161(1):79-86.
  3. Maruta H, Yoshimura Y, Araki A, Kimoto M, Takahashi Y, Yamashita H. 2016 Activation of AMP-activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells. PLOS ONE. 11(6): e0158055.
  4. Aoyama-Sasabe S, Fukushima M, Xin X, Taniguchi A, Nakai Y, Mitsui R, Takahashi Y, Tsuji H, Yabe D, Yasuda K, Kurose T, Inagaki N, Seino Y. 2016 Insulin secretory defect and insulin resistance in isolated impaired fasting glucose and isolated impaired glucose tolerance. J Diabetes Res. in press.
  5. Takahashi Y, Otsuki A, Mori Y, Kawakami Y, Ito H. 2015 Inhibition of leukocyte-type 12-lipoxygenase by guava tea leaves prevents development of atherosclerosis. . Food Chem. 186:2-5.
  6. Suzuki-Yamamoto T, Tanaka S, Tsukayama I, Takafuji M, Hanada T, Arakawa T, Kawakami Y, Kimoto M, Takahashi Y. 2014 Dioscorea japonica extract down-regulates prostaglandin E2 synthetic pathway and induces apoptosis inlung cancer cells. J Clin Biochem Nutr. 55(3):162-167.
  7. Kawakami Y, Hirano S, Kinoshita M, Otsuki A, Suzuki-Yamamoto T; Suzuki M, Kimoto M, Sasabe S, Fukushima M,Kishimoto K, Izumi T, Oga T,Narumiya S, Sugahara M,Miyano M, Yamamoto S, Takahashi Y. 2014 Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chainantibodies. Biochim Biophys Acta. 1840(6): 1625-1633.
  8. Kawakami Y; Hosokawa T; Morinaka T; Irino S; Hirano S; Kobayashi H, Yoshioka A; Suzuki-Yamamoto T; Yokoro M; Kimoto M; Tsuji H; Yamashita H; Doi S; Yutani C, Kato R; Itabe H; Kanada T; Hada T; Takahashi.Y Antiatherogenic effect of guava leaf extracts inhibiting leukocyte-type 12-lipoxygenase activity. Food Chem. in press. (2012)
  9. Kunimoto A, Yokoro M, Murota K, Yamanishi R, Suzuki-Yamamoto T, Suzuki M, Yutani C, Doi S, Hiemori M, Yamashita H, Takahashi Y, Tsuji H, and Kimoto M. Gastrointestinal Digestion and Absorption of Pen j 1, a Major Allergen from Kuruma Prawn, Penaeus japonicas. Biosci. Biotechnol. Biochem. 75(7): 1249-1258. (2011)
  10. Kawakami Y, Yamashita C, Kashiwase Y, Morinaka T, Suzuki-Yamamoto T, Yamashita H, Kimoto M, Tsuji H, Kurahashi Y, Daiyasu H, Toh H, Sugahara M, Miyano M, Yamamoto S, Takahashi Y. Functional expression of single-chain antibody to leukotriene C(4). Biochem Biophys Res Commun. 392(3): 421-425.(2010)
  11. Komiyama N, Hiemori M, Kimoto M, Suzuki M, Yamashita H, Takahashi Y and Tsuji H. Preparation and epitope mapping of a monoclonal antibody against Tri a Bd 27K, a wheat major allergen. Biosci. Biotechnol. Biochem. 73: 2113-2116. (2009)
  12. Kawakami Y, Kubota N, Ekuni N, Suzuki-Yamamoto T, Kimoto M, Yamashita H, Tsuji H, Yoshimoto T, Jisaka M, Tanaka J, Fujimura HF, Miwa Y, Takahashi Y. Tumor-suppressive lipoxygenases inhibit the expression of c-myc mRNA coding region determinant-binding protein/insulin-like growth factor II mRNA-binding protein 1 in human prostate carcinoma PC-3 cells. Biosci. Biotechnol. Biochem. 73: 1811-1817. (2009)
  13. Kawakami Y, Nakamura T, Hosokawa T, Suzuki-Yamamoto T, Yamashita H, Kimoto M, Tsuji H, Yoshida H, Hada H, Takahashi Y. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. Prostag. Leukotr. Ess. 80: 239-245. (2009)
  14. Yamashita H, Maruta H, Jozuka M, Kimura R, Iwabuchi H, Yamato M, Saito T, Fujisawa K, Takahashi Y, Kimoto M, Hiemori M, Tsuji H. Effects of acetate on lipid metabolism in muscles and adipose tissues of type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biosci. Biotechnol. Biochem. 73: 570-6. (2009)
  15. Wen Y, Gu J, Chakrabarti SK, Aylor K, Marshall J, Takahashi Y, Yoshimoto T, Nadler JL. The role of 12/15-lipoxygenase in the expression of interleukin-6 and tumor necrosis factor-alpha in macrophages. Endocrinology 148:1313-22. (2007)
  16. Takahashi Y, Zhu H, Xu W, Murakami T, Iwasaki T, Hattori H, Yoshimoto T. Selective uptake and efflux of cholesteryl linoleate in LDL by macrophages expressing 12/15-lipoxygenase. Biochem Biophys Res Commun. 338: 128-135. (2005)
  17. Kawajiri H, Piao Y, Takahashi Y, Murakami T, Hamanaka N, Yoshimoto T. Synthesis of 8,9-leukotriene A(4) by murine 8-lipoxygenase. Biochem Biophys Res Commun. 338: 144-148. (2005)
  18. Takahashi Y, Zhu H, Yoshimoto T. Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis. Antioxid. Redox Signal. 7: 425-431. (2005)



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