教員紹介

氏名
  山下 広美 YAMASHITA, Hiromi

職位
  教授
E-Mail
  yamashit●fhw.oka-pu.ac.jp(●を@に変更)
研究室番号
  6201







担当科目
  【学部】食品材料学、食生活論(食と健康)、栄養学総論(看護・保健福祉)、食品学実験II
【博士課程】食品生化学特論、食品栄養学特別研究
【研究室学生】卒論生(3名)大学院(前期;2名、後期;1名)
研究テーマ
  先進国や一部の開発途上国においても糖尿病の増加は深刻な社会問題となっています。糖尿病の中でも生活習慣との関連が深い2型糖尿病を予防するには、肥満の予防・進行防止が不可欠です。本研究室では肝臓や脂肪組織、骨格筋における「脂質代謝・糖質代謝の制御機構」とそれら代謝に影響を及ぼす「食品成分の検索」、また最近では「酢酸の生理機能」に注目し「酢酸の体脂肪蓄積抑制効果」について動物や細胞レベルで研究を行っています。
主な研究業績
(論文)
 
  1. Yoshimura Y, Araki A, Maruta H, Takahashi Y and Yamashita H, Molecular Cloning of Rat acss3 and Characterization of Mammalian Propionyl-CoA Synthetase in the Liver Mitochondrial Matrix, The Journal of Biochemistry,161(3):279-289(2017)
  2. Araki A, Yoshimura Y, Yamaguchi Y, Maruta H, Kimoto M,Takahashi Y and Yamashita H, Effect of exercise training with intake of acetic acid on lipid metabolism and endurance performance, 岡山県立大学保健福祉学部紀要、23巻、21-32(2017)doi/10.15009/00001966
  3. Hitomi Maruta, Yukihiro Yoshimura, Aya Araki, Masumi Kimoto, Yoshitaka Takahashi, Hiromi Yamashita, Activation of AMP-activated Protein Kinase and Stimulation of Energy Metabolism by Acetic Acid in L6 Myotube Cells, PLOS ONE,11(6)(2016) , DOI:10.1371/journal.pone.01580554.
  4. Araki A, Yoshimura Y, Maruta H, Kimoto M, Takahashi Y and Yamashita H, Changes in the 5’-AMP concentration ofskeletal muscles on acetic acid treatment under fed or starved conditions in rats, Annals of Obesity & Disorders, 1(3): 1013,(2016)
  5. Hiromi Yamashita, Biological function of acetic acid -Improvement of obesity and glucose tolerance by acetic acid in type 2 diabetic rats-, Critical Reviews in Food Science and Nutrition, 56: S171-S175 (2016).
  6. 山下広美、地域食材大百科 第14巻 菓子類、あん、ジャム・マーマレード、日本栄養・食糧学会誌(2015)
  7. Hitomi Yumioka-Ito, Ryo Misaki, Miyuki Yokoro, Makiko Suzuki, Hiromi Yamashita, Miki Hiemori-Kondo, Masumi Kimoto, Ko Kato, Kazuhito Fujiyama, Hideaki Tsuji, Cloning of a cDNA encoding the Gly m Bd 28K precursor and its vacuole transport in tobacco BY2 suspension-cultured cells,Journal of Nutritional Science and Vitaminology, 60, 129-139(2014)
  8. 山下広美、実験動物を用いた酢酸の肥満抑制効果の評価、岡山実験動物研究会報、第30号、8-10(2014)
  9. 山下広美、酢酸の生理機能性、日本栄養・食糧学会誌、第67巻、171-176(2014)
  10. 我如古菜月、神野景子、山下広美、日本・中国・韓国料理における酢の使用に関する調査研究‐東アジア3料理様式における主材料と酢の組み合わせの違いの調査‐、家政学研究、Vol.60(2)、1-6 (2013).
  11. 我如古菜月、松本侑子、木本眞順美、山下広美、行事食の認知と経験を通した現在の調理文化の調査研究-岡山県と島根県の比較-、岡山県立大学保健福祉学部紀要、第20巻、21-29(2013)
  12. Vision 岡山、2013年8月26日、ハローズ食育テーマの弁当発売 県立大学と産学連携
  13. 山陽新聞、2013年8月10日日刊、ハローズ栄養バランス弁当発売‐野菜中心や和食3種類‐
  14. 「お酢で延ばそう健康寿命!」生き生き栄養楽、山陽新聞夕刊、平成25年2月16日(土)
  15. 我如古菜月、石井展子、多賀友里恵、木本眞順美、辻英明、山下広美、果実浸漬酢の酸味抑制効果の検討、美味技術学会誌、11巻2号、15-21(2012)
  16. Kosaku Uyeda, and Hiromi Yamashita, Carbohydrate-responsive element binding protein, in Lennarz, W.J. and Lane M.D. (eds.) The Encyclopedia of Biological Chemistry, vol.1, 374-378 (2013), Waltham, MA: Academic Press.
  17. Akiko Kirino, Yuka Takasuka, Asami Nishi, Satoko Kawabe, Hiromi Yamashita, Masumi Kimoto, Hideyuki Ito, Hideaki Tsuji, Analysis and functionality of major polyphenolic components of Polygonum cuspidatum1 (Itadori), JNSV (2012) 278-286, 58(4) (2012)
  18. Miyuki Yokoro, Makiko Suzuki, Kaeko Murota, Hiromi Yamashita, Yoshitaka Takahashi, Hideaki Tsuji, Masumi Kimoto, Asymmetric Dimethylarginine, an Endogenous NOS Inhibitor, Is Actively Metabolized in Rat Erythrocytes, Biosci. Biotechnol. Biochem., 76(7), 1334-1342 (2012)
  19. Miyuki Yokoro, Makiko Suzuki, Machiko Yatani, Hiromi Yamashita, Yoshitaka Takahashi, Hideaki Tsuji, Masumi Kimoto, Dvelopment of an enzyme-linked immunosorbent assay system for the determination of asymmetric dimethylarginine using a specific monoclonal antibody, Biosci. Biotechnol. Biochem., 76(2), 400-403 (2012)
  20. Yuki Kawakami, Tomoko Hosokawa, Tomoko Morinaka, Shioka Irino, Shiori Hirano, Hirokazu Kobayashi, Akiko Yoshioka, Toshiko Suzuki-Yamamoto, Miyuki Yokoro, Masumi Kimoto, Hideaki Tsuji, Hiromi Yamashita, Shinobu Doi, Chikao Yutani, Rina Kato, Hiroyuki Itabe, Teruyuki Kanada, Takahiko Hada, Yoshitaka Takahashi, Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity, Food Chemistry, 131, 1069-1075 (2012)
  21. 我如古菜月、石井展子、多賀友里恵、木本眞順美、辻英明、山下広美、果実浸漬酢の酸味抑制効果の検討、美味技術学会誌、11巻2号、15-21(2012)
  22. Kunimoto, A., Yokoro, M., Murota, K., Yamanishi, R., Suzuki-Yamamoto, T., Suzuki, M., Yutani, C., Doi, S., Hiemori, M., Yamashita, H., Takahashi, Y., Tsuji, H., Kimoto, M., Gastrointestinal Digestion and Absorption of Pen j 1, a Major Allergen from Kuruma Prawn, Penaeus Japonicus, Biosci. Biotechnol. Biochem. 75(7), 1249-1258 (2011).
  23. Kawakami, Y., Yamashita, C., Kashiwase, Y., Morinaka, T., S.-Yamamoto, T., Yamashita, H., Kimoto, M., Tsuji, H., Kurahashi, Y., Daiyasu, H., Toh, H., Sugahara, M., Miyano, M., Yamamoto, S., Takahashi, Y., Functional expression of single-chain antibody to leulotriene C4, Biochem. Biophys. Res. Commun., 392, 421-425 (2010).
  24. Hiemori, M., Yoshida, Y., Kimoto, M., Yamashita, H., Takahashi, K., Takahashi, K., Komiyama, N., and Tsuji. H., Investigation of multiple forms of Tri a Bd 27K, a major wheat allergen, by immunoblotting analysis. Biosci. Biotechnol. Biochem. 74(1), 199-202 (2010).
  25. Kawakami, Y., Kubota, N., Ekuni, N., Suzuki-Yamamoto, T., Kimoto, M., Yamashita, H., Tsuji, H., Yoshimoto, T., Jisaka, M., Tanaka, J., Fujimura, H., Miwa, Y., Takahashi, Y., Tumor-suppressive Lipoxygenases Inhibit Expression of c-myc mRNA Coding Region Determinant-binding Protein/Insulin-like Growth Factor II mRNA-binding Protein 1 in Human Prostate Carcinoma PC-3 Cells, Biosci. Biotechnol. Biochem. 73(8), 1811-1817 (2009).
  26. Komiyama, N., Hiemori, M., Kimoto, M., Suzuki, M., Yamashita, H., Takahashi Y., Tsuji, H., Preparation and epitope mapping of a monoclonal antibody against Tri a Bd 27K, a wheat major allergen, Biosci. Biotechnol. Biochem. 73(9), 2113-2116 (2009).
  27. Kawakami, Y., Nakamura, T., Hosokawa, T., Suzuki-Yamamoto, T., Yamashita, H., Kimoto, M., Tsuji, H., Yoshida, H., Hada, T., Takahashi, Y., Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms, Prostaglandins, Leukotrienes and Essential Fatty Acids, 80, 239-245 (2009).
  28. Ishikawa, A., Hiemori, M., Kimoto, M., Yamashita, H., Tsuji, H., Development of a method for the determination of g-aminobutyric acid in foodstuffs, J. Nutr. Sci. Vitaminol. 55(3):292-5 (2009).
  29. Kunimoto, A., Sisino,T., Sakai, K., Matsumoto, T., Takahashi, K., Yamashita, H., Hiemori, M., Tsuji, H., Kimoto, M., Molecular cloning and allergenicity of Pen j 1, a major allergen of Kuruma Prawn, Penaeus japonicus, Biosci. Biotechnol. Biochem. 73(4), 840-848 (2009).
  30. Yamashita, H., Maruta, H., Jozuka, M., Kimura, R., Iwabuchi, H., Yamato, M., Saito, T., Fujisawa, K., Takahashi, Y., Kimoto, M., Hiemori, M., Tsuji, H., Effects of acetate on lipid metabolism in muscle and adipose tissue of type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, Biosci. Biotechnol. Biochem. 73(3), 570-576 (2009).
  31. Kimoto, M., Suzuki, M., Komiyama, N., Kunimoto, A., Yamashita, H., Hiemori, M., Takahashi, K., Tsuji, H., Isolation and molecular cloning of a major wheat allergen, Tri a Bd 27K, Biosci. Biotech. Biochem., (2009) 73(1), 85-92.
  32. Hiemori, M., Eguchi, Y., Kimoto, M., Yamashita, H., Takahashi, K., Takahashi, K., Tsuji, H., Characterization of new 18-kDa IgE-binding proteins in beer, Biosci. Biotechnol. Biochem. (2008) 72 (4), 1095-1098.
  33. Yamashita, H., Fujisawa, K., Ito, E., Idei, S., Kawaguchi, N., Kimoto, M., Hiemori, M., Tsuji, H., Improvement of obesity and glucose tolerance by acetate in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, Biosci. Biotechnol. Biochem. (2007) 71(5), 1236-1243.
  34. Itsuki-Yoneda, A. Kimoto, M., Tsuji, H., Hiemori, M., Yamashita, H., Effect of hypolipidemic drug, di (2-ethylhexyl) phthalate, on mRNA expression associating fatty acid and acetate metabolism in rat tissues, Biosci. Biotechnol. Biochem. (2007) 71(2), 414-420.
  35. Ishikawa, A., Yamashita, H., Hiemori, M., Inagaki, E., Kimoto, M., Okamoto, M., Tsuji, H., Memon, A.N., Mohammadi, A., Natori, Y. Characterization of Inhibitors of Postprandial Hyperglycemia from the Leaves of Nerium indicum, J. Nutr. Sci. Vitaminol. (2007) 53, 166-173.
  36. Hiromi Yamashita, Ai Itsuki, Masumi Kimoto, Miki Hiemori, Hideaki Tsuji, Acetate generation in rat liver mitochondria; acetyl-CoA hydrolase activity is demonstrated by 3-ketoacyl-CoA thiolase, Biochim. Biophys. Acta, (2006) 1761, 17-23.
  37. Miki Hiemori, Hitomi Ito, Masumi Kimoto, Hiromi Yamashita, Keito Nishizawa, Nobuyuki Maruyama, Shigeru Utsumi, Hideami Tsuji, Idetification of the 23-kDa peptide derived from the precursor of Gly m Bd 28K, a majorsoybean allergen, as a new allergen, Biochim. Biophys. Acta, (2004) 1675, 174-183.
  38. Hiromi Yamashita, Yoko Nanba, Miki Onishi, Masumi Kimoto, Miki Hiemori, and Hideaki Tsuji, Identification of a wheat allergen, Tri a Bd 36K, as a peroxidase, Biosci. Biotechnol. Biochem., (2002) 66, 2487-2490.
  39. Hiromi Yamashita, Akemi Fukuura, Tomomi Nakamura, Takao Kaneyuki, Masumi Kimoto, Miki Hiemori, and Hideaki Tsuji, Purification and partial characterization of acetyl-CoA synthetase in rat liver mitochondria, J. Nutr. Sci. Vitaminol., (2002) 48, 359-364.
  40. Kosaku Uyeda, Hiromi Yamashita, Takumi Kawaguchi, Carbohydrate responsive element-binding protein (ChREBP):a key regulator of glucose metabolism and fat strage, Biochm. Pharmacol., (2002) 63, 2075-2080.



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